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Inhibitors of antigen-induced degranulation of RBL-2H3 cells isolated from wheat bran

Journal of the Korean Society for Applied Biological Chemistry volume 55, pages 69–74 (2012)Cite this article

Abstract

Chromatographic separation of ethanol extract of wheat bran led to the isolation of five 5-alk(en)ylresorcinols, four aliphatic compounds, and one phenolic glycoside. These were, respectively: 5-n-heptadecylresorcinol (1), 5-n-14′-(Z)-heneicosylresorcinol (2), 5-n-nonadecylresorcinol (3), 5-n-heneicosylresorcinol (4), 5-n-tricosylresorcinol (5), 1-O-(9Z,12Z,15Z-octadecatrienoate) glycerol (6), 2-linoleoylglycerol (7), 1-O-(9Z,12Z-octadecatrienoate)glycerol (8), pinellic acid (9), and tachioside (10). Their structures were determined by 1D- & 2D-NMR and mass spectroscopy data analysis. The inhibitory effects of isolated constituents on the release of β-hexosaminidase from RBL-2H3 cells were examined. Inhibition was shown by 5-n-nonadecylresorcinol (3), 5-n-heneicosylresorcinol (4), pinellic acid (9), and tachioside (10).

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Authors and Affiliations

  1. Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion, Suwon, 443-766, Republic of Korea

    Seong Su Hong & Joa Sub Oh

  2. College of Pharmacy, Dankook University, Cheonan, 330-714, Republic of Korea

    Joa Sub Oh

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  1. Seong Su Hong
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  2. Joa Sub Oh
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Correspondence to Joa Sub Oh.

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Hong, S.S., Oh, J.S. Inhibitors of antigen-induced degranulation of RBL-2H3 cells isolated from wheat bran. J Korean Soc Appl Biol Chem 55, 69–74 (2012). https://doi.org/10.1007/s13765-012-0012-5

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  • DOI: https://doi.org/10.1007/s13765-012-0012-5

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